1-[4-(methylsulfonyl)phenyl]ethanone

1-[4-(methylsulfonyl)phenyl]ethanone - Names and Identifiers

Name	4'-Methylsulfonylacetophenone
Synonyms	4'-Mesylacetophenone 4-methylsulfonylacetophenone 4-Methylsulphonylacetophenone 4'-Methylsulfonylacetophenone 4-Methylsulphonyl Acetophenone (4-Methanesulphonylphenyl)-ethanone 1-(4-(methylsufonyl)phenyl)ethanone 1-[4-(methylsulfonyl)phenyl]ethanone Ethanone, 1-[4-(methylsulfonyl)phenyl]- 4-Methyi Sulfonyl Acetophenone, Rofecoxib,
CAS	10297-73-1
EINECS	233-672-0
InChI	InChI=1/C9H10O3S/c1-7(10)8-3-5-9(6-4-8)13(2,11)12/h3-6H,1-2H3

1-[4-(methylsulfonyl)phenyl]ethanone - Physico-chemical Properties

Molecular Formula	C9H10O3S
Molar Mass	198.24
Density	1.3339 (rough estimate)
Melting Point	126-129°C(lit.)
Boling Point	305.56°C (rough estimate)
Flash Point	242°C
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Vapor Presure	3.82E-06mmHg at 25°C
Appearance	yellowish-like powder
Color	White to slightly yellow
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5250 (estimate)
MDL	MFCD00025072

1-[4-(methylsulfonyl)phenyl]ethanone - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29144000
Hazard Class	IRRITANT

1-[4-(methylsulfonyl)phenyl]ethanone - Introduction

4-methylsulfonylacetophenone, the chemical formula C8H9KS, is also known as Methylthone. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: 4-Methylsulfonylacetophenone is a colorless to pale yellow solid.
-Solubility: It is soluble in common organic solvents (such as ethanol, acetone, chloroform).
-Stability: It is unstable and can decompose or trigger combustion.
-lethal dose: toxic to the human body, fatal.

Use:
-Laboratory research purposes: 4-methylsulfonyl acetophenone can be used as an intermediate in organic synthesis reactions, including drug synthesis, perfume synthesis and other fields.
-Stimulant: Due to its structural similarity to the drug MDMA, 4-methylsulfonylacetophenone may be misused as a banned drug to achieve similar stimulatory or hallucinogenic effects.

Preparation Method:
A commonly used preparation method is to react acetophenone and 4-methylsulfone under the catalysis of hydrochloric acid to obtain 4-methylsulfonyl acetophenone.

Safety Information:
-Irritating to eyes and skin, rinse with plenty of water immediately after contact.
-Inhalation of this substance can cause respiratory irritation. Ensure good ventilation and respiratory protection equipment.
- 4-methyl sulfonyl acetophenone is a flammable substance, avoid contact with heat sources, to prevent sparks, fire caused by combustion or explosion.
-Due to the potential risk of abuse, the use, storage and distribution of 4-methylsulfonylacetophenone should be subject to national and local laws and regulations to ensure safe use.

Last Update：2024-04-09 02:00:40